Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010581)
Formula Reactant Guanfacine Product Guanfacine Metabolite M6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010578 Guanfacine 3-Hydroxyguanfacine Oxidation - Oxidation Guanfacine [1]
MR011447 Guanfacine Guanfacine dihydro-diol Multi-steps Reaction - Epoxidation; hydratuon Guanfacine [1]
MR010585 Guanfacine Guanfacine Metabolite M1 Multi-steps Reaction - Epoxidation; hydration Guanfacine [1]
MR010584 Guanfacine Guanfacine Metabolite M4,5,7,8 Conjugation - Glucuronidation Guanfacine [1]
MR011446 Guanfacine Guanfacine Metabolite M4,M5,M7,M8 Conjugation - Glucuronidation Guanfacine [1]
MR011448 Guanfacine HydroxyGuanfacine Unclear - Unclear Guanfacine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010582 Guanfacine Metabolite M6 Guanfacine Metabolite M2 Conjugation - Glucuronidation Guanfacine [1]
MR010583 Guanfacine Metabolite M6 Guanfacine Metabolite M3 Conjugation - Sulfation Guanfacine [1]
References
1 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets

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