Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010584)
Formula Reactant Guanfacine Product Guanfacine Metabolite M4,5,7,8
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010578 Guanfacine 3-Hydroxyguanfacine Oxidation - Oxidation Guanfacine [1]
MR011447 Guanfacine Guanfacine dihydro-diol Multi-steps Reaction - Epoxidation; hydratuon Guanfacine [1]
MR010585 Guanfacine Guanfacine Metabolite M1 Multi-steps Reaction - Epoxidation; hydration Guanfacine [1]
MR011446 Guanfacine Guanfacine Metabolite M4,M5,M7,M8 Conjugation - Glucuronidation Guanfacine [1]
MR010581 Guanfacine Guanfacine Metabolite M6 Oxidation - Oxidation Guanfacine [1]
MR011448 Guanfacine HydroxyGuanfacine Unclear - Unclear Guanfacine [1]
References
1 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets

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