General Information of This Metabolic Reaction (MR) (ID: MR010792)
Formula
SVG example
Unclear
Reactant Naloxone Product Naloxone Metabolite M5
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010797 Naloxone Naloxol Reduction - 6-ketoreduction Naloxone [1]
MR010796 Naloxone Naloxone 3-Glucuronide Conjugation - Glucuronidation Naloxone [2]
MR010794 Naloxone Naloxone Metabolite M10 Unclear - Unclear Naloxone [3]
MR010785 Naloxone Naloxone Metabolite M2 Unclear - Unclear Naloxone [3]
MR010789 Naloxone Naloxone Metabolite M21 Unclear - Unclear Naloxone [3]
MR010791 Naloxone Naloxone Metabolite M23 Unclear - Unclear Naloxone [3]
MR010795 Naloxone Naloxone Metabolite M26 Unclear - Unclear Naloxone [3]
MR010793 Naloxone Naloxone Metabolite M31 Unclear - Unclear Naloxone [3]
MR010787 Naloxone Naloxone Metabolite M4 Unclear - Unclear Naloxone [3]
MR010790 Naloxone Naloxone Metabolite M7 Unclear - Unclear Naloxone [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013820 Oxycodone Oxymorphone Unclear - Unclear Oxycodone [5]
MR001884 Oxycodone hydrochloride Oxymorphone Oxidation - O-Demethylation Oxycodone hydrochloride [6], [7], [8], [9]
MR001905 Oxymorphone Oxymorphone Oxidation - O-Demethylation Oxymorphone [10]
MR010784 Zanubrutinib Zanubrutinib Metabolite M5 Unclear - Unclear zanubrutinib [11]
References
1 Metabolites of naloxone in human urine
2 Effect of naloxone-3-glucuronide and N-methylnaloxone on the motility of the isolated rat colon after morphine
3 Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
4 PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates
5 Metabolism and Disposition of Prescription Opioids: A Review
6 Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54.
7 Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward. J Pharmacol Exp Ther. 2022 Aug;382(2):167-180. doi: 10.1124/jpet.122.001217.
8 Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests. Pharmacogenomics J. 2022 Feb;22(1):25-32. doi: 10.1038/s41397-021-00253-5.
9 Association of CYP2D6 genotype predicted phenotypes with oxycodone requirements and side effects in children undergoing surgery. Ann Transl Med. 2022 Dec;10(23):1262. doi: 10.21037/atm-2022-58.
10 Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87.
11 In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

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