Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010797)
Formula
SVG example
6-ketoreduction
Reactant Naloxone Product Naloxol
Reactant Info Product Info
Metabolic Type Reduction - 6-ketoreduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010796 Naloxone Naloxone 3-Glucuronide Conjugation - Glucuronidation Naloxone [1]
MR010794 Naloxone Naloxone Metabolite M10 Unclear - Unclear Naloxone [2]
MR010785 Naloxone Naloxone Metabolite M2 Unclear - Unclear Naloxone [2]
MR010789 Naloxone Naloxone Metabolite M21 Unclear - Unclear Naloxone [2]
MR010791 Naloxone Naloxone Metabolite M23 Unclear - Unclear Naloxone [2]
MR010795 Naloxone Naloxone Metabolite M26 Unclear - Unclear Naloxone [2]
MR010793 Naloxone Naloxone Metabolite M31 Unclear - Unclear Naloxone [2]
MR010787 Naloxone Naloxone Metabolite M4 Unclear - Unclear Naloxone [2]
MR010792 Naloxone Naloxone Metabolite M5 Unclear - Unclear Naloxone [2]
MR010790 Naloxone Naloxone Metabolite M7 Unclear - Unclear Naloxone [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010782 Zanubrutinib Metabolite M7/M8 Zanubrutinib Metabolite M4 Unclear - Unclear zanubrutinib [4]
References
1 Effect of naloxone-3-glucuronide and N-methylnaloxone on the motility of the isolated rat colon after morphine
2 Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
3 PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates
4 In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

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