Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR011362)
Formula	O-deethylation
	Reactant	LNP023		Product	LNP023 Metabolite M1
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - O-deethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR011361	LNP023	LNP023 Metabolite M2	Conjugation - Glucuronidation	LNP023	[1], [2]
MR011359	LNP023	LNP023 Metabolite M4	Oxidation - Hydroxylation	LNP023	[1]

References
1	Pharmacokinetics and metabolism of LNP023 in rats by liquid chromatography combined with electrospray ionization-tandem mass spectrometry
2	Absorption, Distribution, Metabolism, and Excretion of [(14)C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies

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