Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011359)
Formula	Hydroxylation
	Reactant	LNP023	Product	LNP023 Metabolite M4
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - Hydroxylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR011362	LNP023	LNP023 Metabolite M1	Oxidation - O-deethylation	LNP023	[1]
MR011361	LNP023	LNP023 Metabolite M2	Conjugation - Glucuronidation	LNP023	[1], [2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR011360	LNP023 Metabolite M4	LNP023 Metabolite M3	Oxidation - Oxidation	LNP023	[1], [2]

References
1	Pharmacokinetics and metabolism of LNP023 in rats by liquid chromatography combined with electrospray ionization-tandem mass spectrometry
2	Absorption, Distribution, Metabolism, and Excretion of [(14)C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies

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