Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011384)
Formula
SVG example
S-oxidation
Reactant Chlorpromazine Product Opromazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - S-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011381 Chlorpromazine Chlorpromazine-N-oxide Unclear - Unclear Chlorpromazine [1]
MR011382 Chlorpromazine Dedimethylchlorpromazine Unclear - Unclear Chlorpromazine [1]
MR011383 Chlorpromazine Demonomethylchlorpromazine Unclear - Unclear Chlorpromazine [1]
MR011380 Chlorpromazine Hydroxychlorpromazine Oxidation - 7-hydroxylation Chlorpromazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000645 Chlorpromazine hydrochloride Opromazine Unclear Chlorpromazine hydrochloride [2], [3]
References
1 DrugBank(Pharmacology-Metabolism):Chlorpromazine
2 Classics in Chemical Neuroscience: Chlorpromazine ACS Chem Neurosci. 2019 Jan 16;10(1):79-88. doi: 10.1021/acschemneuro.8b00258.
3 Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis. Food Chem. 2023 Mar 1;403:134298. doi: 10.1016/j.foodchem.2022.134298.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.