Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000645)
Formula
CYP3A4 ...
SVG example
Reactant Chlorpromazine hydrochloride Product Opromazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000644 Chlorpromazine hydrochloride Chlorpromazine-N-oxide Unclear Chlorpromazine hydrochloride [1]
MR000642 Chlorpromazine hydrochloride Demonomethylchlorpromazine Unclear Chlorpromazine hydrochloride [1], [2]
MR000643 Chlorpromazine hydrochloride Hydroxychlorpromazine Oxidation - 7-Hydroxylation Chlorpromazine hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011384 Chlorpromazine Opromazine Oxidation - S-oxidation Chlorpromazine [3]
References
1 Classics in Chemical Neuroscience: Chlorpromazine ACS Chem Neurosci. 2019 Jan 16;10(1):79-88. doi: 10.1021/acschemneuro.8b00258.
2 Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis. Food Chem. 2023 Mar 1;403:134298. doi: 10.1016/j.foodchem.2022.134298.
3 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.

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