Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011628)
Formula Reactant MLN4924 Product MLN4924 Metabolite M22,10b
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Glucuronidation; Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011622 MLN4924 MLN4924 Metabolite M1 Oxidation - Hydroxylation MLN4924 [1]
MR011627 MLN4924 MLN4924 Metabolite M16 Conjugation - Glucuronidation MLN4924 [1]
MR011624 MLN4924 MLN4924 Metabolite M3 Oxidation - Hydroxylation MLN4924 [1]
MR011626 MLN4924 MLN4924 Metabolite M7 Oxidation - N-dealkylation MLN4924 [1]
References
1 Metabolism and Disposition of [(14)C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors

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