Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011622)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant MLN4924 Product MLN4924 Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011627 MLN4924 MLN4924 Metabolite M16 Conjugation - Glucuronidation MLN4924 [1]
MR011628 MLN4924 MLN4924 Metabolite M22,10b Multi-steps Reaction - Glucuronidation; Hydroxylation MLN4924 [1]
MR011624 MLN4924 MLN4924 Metabolite M3 Oxidation - Hydroxylation MLN4924 [1]
MR011626 MLN4924 MLN4924 Metabolite M7 Oxidation - N-dealkylation MLN4924 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011623 MLN4924 Metabolite M1 MLN4924 Metabolite M2 Oxidation - Oxidation MLN4924 [1]
References
1 Metabolism and Disposition of [(14)C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors

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