Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011860)
Formula
SVG example
Unclear
Reactant Amifloxacin Product N-desmethyl-Amifloxacin
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011861 Amifloxacin Amifloxacin N-oxide Unclear - Unclear Amifloxacin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006891 Lomefloxacin N-Desmethylamifloxacin Oxidation - N-demethylation Lomefloxacin [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006892 N-Desmethylamifloxacin Lomefloxacin glucuronide metabolite Conjugation - Glucuronidation Lomefloxacin [3]
References
1 In vitro activities of amifloxacin and two of its metabolites
2 Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother. 1992 May;36(5):942-8.
3 Pubchem:Lomefloxacin

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