Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012145)
Formula
UGT1A9 ...
SVG example
Unclear
Reactant SN-38 Product SN-38 glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007484 SN-38 SN-38G Conjugation - Glucuronidation SN-38 [1], [2]
MR013227 SN-38 10-O-glucuronyl-SN-38 Conjugation - O-gluccuronidation Sacituzumab govitecan [3]
MR001227 SN-38 Glucuronidated Sn-38 Conjugation - Glucuronidation Irinotecan hydrochloride [4], [5], [6]
References
1 Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
2 Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics
3 New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9
4 Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients Drug Metab Dispos. 2000 Apr;28(4):423-33.
5 Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: A new concept. Biochem Biophys Res Commun. 2023 Jul 12;665:19-25. doi: 10.1016/j.bbrc.2023.04.109.
6 Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model. Br J Pharmacol. 2023 May;180(10):1362-1378. doi: 10.1111/bph.16020.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.