Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001227)
Formula
SVG example
Glucuronidation
Reactant SN-38 Product Glucuronidated Sn-38
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007484 SN-38 SN-38G Conjugation - Glucuronidation SN-38 [1], [2]
MR013227 SN-38 10-O-glucuronyl-SN-38 Conjugation - O-gluccuronidation Sacituzumab govitecan [3]
MR013627 SN-38 SN-38 G Unclear T-0128 [4]
MR012145 SN-38 SN-38 glucuronide Unclear - Unclear Etirinotecan pegol [5]
References
1 Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
2 Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics
3 New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9
4 Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors
5 Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors

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