Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012265)
Formula
CYP
SVG example
N-dealkylation
Reactant EPZ-5676 Product EPZ-5676 M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012262 EPZ-5676 EPZ-5676 M1 Oxidation - Hydroxylation EPZ-5676 [1]
MR012264 EPZ-5676 EPZ-5676 M5 Oxidation - Hydroxylation EPZ-5676 [1]
MR012263 EPZ-5676 EPZ-5676 M6 Oxidation - N-oxidation EPZ-5676 [1]
References
1 Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

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