Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012667)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant LY-2603618 Product LY-2603618 Metabolite H2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012669 LY-2603618 LY-2603618 Metabolite H3 Oxidation - Hydroxylation LY-2603618 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012668 LY-2603618 Metabolite H2 LY-2603618 Metabolite H1 Unclear - Unclear LY-2603618 [1]
References
1 Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors. Xenobiotica. 2014 Sep;44(9):827-41.

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