General Information of This Metabolic Reaction (MR) (ID: MR012677)
Formula
SVG example
Hydroxylation
Reactant MGI-114 Product Irofulven metabolite 4 (M4)
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012689 MGI-114 Irofulven metabolite 3 (M3) Oxidation - Hydroxylation MGI-114 [1]
MR012680 MGI-114 Irofulven metabolite 6 (M6) Unclear - Unclear MGI-114 [1]
MR012687 MGI-114 Irofulven-glucuronide conjugate (M') Conjugation - Glucuronidation MGI-114 [1]
MR012688 MGI-114 Irofulven-glutathione conjugate (M1) Conjugation - Glutathione conjugation MGI-114 [1]
MR012682 MGI-114 Opened-ring metabolite (M2) Unclear - Unclear MGI-114 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012678 Irofulven metabolite 4 (M4) Irofulven metabolite 5 (M5) Unclear - Unclear MGI-114 [1]
MR012686 Irofulven metabolite 4 (M4) M4-glucuronide conjugate (M'4) Conjugation - Glucuronidation MGI-114 [1]
References
1 Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors

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