Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012688)
Formula Reactant MGI-114 Product Irofulven-glutathione conjugate (M1)
Reactant Info Product Info
Metabolic Type Conjugation - Glutathione conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012689 MGI-114 Irofulven metabolite 3 (M3) Oxidation - Hydroxylation MGI-114 [1]
MR012677 MGI-114 Irofulven metabolite 4 (M4) Oxidation - Hydroxylation MGI-114 [1]
MR012680 MGI-114 Irofulven metabolite 6 (M6) Unclear - Unclear MGI-114 [1]
MR012687 MGI-114 Irofulven-glucuronide conjugate (M') Conjugation - Glucuronidation MGI-114 [1]
MR012682 MGI-114 Opened-ring metabolite (M2) Unclear - Unclear MGI-114 [1]
References
1 Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors

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