Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012682)
Formula
SVG example
Unclear
Reactant MGI-114 Product Opened-ring metabolite (M2)
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012689 MGI-114 Irofulven metabolite 3 (M3) Oxidation - Hydroxylation MGI-114 [1]
MR012677 MGI-114 Irofulven metabolite 4 (M4) Oxidation - Hydroxylation MGI-114 [1]
MR012680 MGI-114 Irofulven metabolite 6 (M6) Unclear - Unclear MGI-114 [1]
MR012687 MGI-114 Irofulven-glucuronide conjugate (M') Conjugation - Glucuronidation MGI-114 [1]
MR012688 MGI-114 Irofulven-glutathione conjugate (M1) Conjugation - Glutathione conjugation MGI-114 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012684 Opened-ring metabolite (M2) M2-glucuronide conjugate (M'2) Conjugation - Glucuronidation MGI-114 [1]
MR012683 Opened-ring metabolite (M2) M2-glutathione conjugate (M'1) Conjugation - Glutathione conjugation MGI-114 [1]
MR012685 Opened-ring metabolite (M2) M2-glutathione conjugate (M0) Conjugation - Glutathione conjugation MGI-114 [1]
References
1 Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors

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