Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012802)
Formula Reactant UK-453,061 Product UK-453,061 Metabolite M10
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012801 UK-453,061 UK-453,061 Metabolite M1 Unclear UK-453,061 [1]
MR012803 UK-453,061 UK-453,061 Metabolite M12 Unclear UK-453,061 [1]
MR012794 UK-453,061 UK-453,061 Metabolite M13 Unclear UK-453,061 [1]
MR012809 UK-453,061 UK-453,061 Metabolite M15 Unclear UK-453,061 [1]
MR012792 UK-453,061 UK-453,061 Metabolite M17 Oxidation - Mono-oxidation UK-453,061 [1]
MR012810 UK-453,061 UK-453,061 Metabolite M18 Unclear UK-453,061 [1]
MR012808 UK-453,061 UK-453,061 Metabolite M19 Unclear UK-453,061 [1]
MR012796 UK-453,061 UK-453,061 Metabolite M21 Unclear UK-453,061 [1]
MR012806 UK-453,061 UK-453,061 Metabolite M3 Multi-steps Reaction - Glucuronidation; monohydroxylation UK-453,061 [1]
MR012804 UK-453,061 UK-453,061 Metabolite M4 Multi-steps Reaction - Oxidationn; glucuronidation; hydrolysis UK-453,061 [1]
MR012805 UK-453,061 UK-453,061 Metabolite M5 Unclear UK-453,061 [1]
MR012807 UK-453,061 UK-453,061 Metabolite M6 Multi-steps Reaction - Glucuronidation; monohydroxylation UK-453,061 [1]
References
1 Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. Drug Metab Dispos. 2010 May;38(5):789-800.

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