Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012857)
Formula
SVG example
N-oxidation
Reactant Aniline Product N-Hydroxyaniline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012858 Aniline 2-aminophenol Unclear Aniline [1]
MR012856 Aniline 4-aminophenol Oxidation - Aromatic hydroxylation Aniline [1]
MR012853 Aniline Acetanilide-d5 Unclear Aniline [2]
MR005148 Aniline 2-aminophenol Oxidation - Hydrolyzationn Phenazopyridine [3], [4], [5]
MR005146 Aniline 4-aminophenol Oxidation - Hydrolyzationn Phenazopyridine [3], [4], [5]
References
1 Aniline and its metabolites generate free radicals in yeast
2 Human metabolism and excretion kinetics of aniline after a single oral dose
3 Metabolism and disposition of phenazopyridine in rat
4 The metabolism and excretion of phenazopyridine hydrochloride in animals and man
5 Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs

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