Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012856)
Formula
SVG example
Aromatic hydroxylation
Reactant Aniline Product 4-aminophenol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - Aromatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012858 Aniline 2-aminophenol Unclear Aniline [1]
MR012853 Aniline Acetanilide-d5 Unclear Aniline [2]
MR012857 Aniline N-Hydroxyaniline Oxidation - N-oxidation Aniline [3]
MR005148 Aniline 2-aminophenol Oxidation - Hydrolyzationn Phenazopyridine [4], [5], [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009056 4-chloro aniline 4-amino phenol Unclear - Unclear BMS-986205 [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005147 4-aminophenol N-acetyl-4-Aminophenol Conjugation - Acetylation Phenazopyridine [4], [5], [6]
References
1 Aniline and its metabolites generate free radicals in yeast
2 Human metabolism and excretion kinetics of aniline after a single oral dose
3 Aniline derivative-induced methemoglobin in rats
4 Metabolism and disposition of phenazopyridine in rat
5 The metabolism and excretion of phenazopyridine hydrochloride in animals and man
6 Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs
7 Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program

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