Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012911)
Formula
SVG example
Reactant NSC-63853 Product 17-alpha-hydroxyprogesterone
Reactant Info Product Info
Metabolic Enzyme Cytochrome b5 type B (CYB5B) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012915 NSC-63853 Androsterone Unclear NSC-63853 [1]
MR012916 NSC-63853 Cortisol Unclear NSC-63853 [2]
MR012912 NSC-63853 Dehydroepiandrosterone Unclear NSC-63853 [3]
MR012914 NSC-63853 Etiocholanolone Unclear NSC-63853 [1]
MR012913 NSC-63853 Isoandrosteron Unclear NSC-63853 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005143 Hydroxyprogesterone caproate 17alpha- Hydroxyprogesterone Hydrolysis - Hydrolyzation Hydroxyprogesterone caproate [4], [5]
MR002173 Progesterone 17-OH progesterone Oxidation - Hydroxylation Progesterone [6]
References
1 The conversion in vivo of 17-alpha-hydroxypregnenolone to dehydroisoandrosterone and other 17-ketosteroids
2 The conversion in vitro of 17-hydroxypregnenolone to cortisol by a human adrenal tumor
3 The role of cytochrome b5 in the biosynthesis of androgens by human P450c17
4 Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate
5 The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth. Am J Obstet Gynecol. 2017 Sep;217(3):369.e1-369.e9.
6 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.

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