Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002173)
Formula
SVG example
Hydroxylation
Reactant Progesterone Product 17-OH progesterone
Reactant Info Product Info
Metabolic Enzyme Steroid 17-alpha-monooxygenase (CYP17A1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002172 Progesterone 11-deoxycorticosterone Oxidation - Hydroxylation Progesterone [1]
MR002170 Progesterone 16alpha-hydroxyprogesterone Oxidation - Hydroxylation Progesterone [1]
MR002175 Progesterone 20 a hydroxy- delta 4 a- prenolone Oxidation - Hydroxylation Progesterone [2]
MR002176 Progesterone 2alpha-hydroxyprogesterone Oxidation - Hydroxylation Progesterone [3]
MR002174 Progesterone 5 alpha-dihydroprogesterone Unclear Progesterone [1]
MR002171 Progesterone 6beta-hydroxyprogesterone Oxidation - Hydroxylation Progesterone [1], [3]
MR002178 Progesterone Pregnanediol Oxidation - Hydroxylation Progesterone [4]
MR002179 Progesterone Pregnanetriol Oxidation - Hydroxylation Progesterone [4]
MR002177 Progesterone Pregnanolone Oxidation - Hydroxylation Progesterone [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005143 Hydroxyprogesterone caproate 17alpha- Hydroxyprogesterone Hydrolysis - Hydrolyzation Hydroxyprogesterone caproate [5], [6]
MR012911 NSC-63853 17-alpha-hydroxyprogesterone Unclear NSC-63853 [7]
References
1 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
2 DrugBank(Pharmacology-Metabolism)Progesterone
3 Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model Reprod Sci. 2015 Dec;22(12):1577-86. doi: 10.1177/1933719115589414.
4 FDA:Progesterone
5 Transplacental transfer and metabolism of 17-alpha-hydroxyprogesterone caproate
6 The association among cytochrome P450 3A, progesterone receptor polymorphisms, plasma 17-alpha hydroxyprogesterone caproate concentrations, and spontaneous preterm birth. Am J Obstet Gynecol. 2017 Sep;217(3):369.e1-369.e9.
7 CONVERSION OF 17-ALPHA-HYDROXYPREGNENOLONE TO 17-ALPHA-HYDROXYPROGESTERONE BY THE CANINE TESTIS IN VIVO

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.