Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013043)
Formula
UGT1A10 ...
SVG example
Unclear
Reactant Darexaban maleate Product Darexaban glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013039 Darexaban maleate Darexaban maleate Metabolite M5 Unclear - Unclear Darexaban maleate [1]
MR013041 Darexaban maleate Darexaban N-oxides Unclear - Unclear Darexaban maleate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013044 Darexaban glucuronide Darexaban maleate Metabolite M2 Unclear - Unclear Darexaban maleate [1]
MR013045 Darexaban glucuronide Darexaban maleate Metabolite M4 Unclear - Unclear Darexaban maleate [1]
References
1 Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans
2 Identification of enzymes responsible for the N-oxidation of darexaban glucuronide, the pharmacologically active metabolite of darexaban, and the glucuronidation of darexaban N-oxides in human liver microsomes

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