Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013078)
Formula
SVG example
Hydroxylation
Reactant TAK-438 N-sulfate Product Vonoprazan M--Sul
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013077 Vonoprazan TAK-438 N-sulfate Oxidation - Sulfonation Vonoprazan [1], [2]
References
1 Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date
2 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.