Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013077)
Formula
SVG example
Sulfonation
Reactant Vonoprazan Product TAK-438 N-sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 2A1 (SULT2A1) DME Info
Metabolic Type Oxidation - Sulfonation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013079 Vonoprazan N-demethylated TAK-438 Oxidation - N-demethylation Vonoprazan [1], [2]
MR013073 Vonoprazan Vonoprazan M- Unclear - Unclear Vonoprazan [3], [2]
MR013080 Vonoprazan Vonoprazan M- Unclear - Unclear Vonoprazan [3], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013078 TAK-438 N-sulfate Vonoprazan M--Sul Oxidation - Hydroxylation Vonoprazan [3], [2]
References
1 Assessments of CYP?inhibition?based drug-drug interaction between vonoprazan and poziotinib in?vitro and in?vivo
2 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.
3 Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.