Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013211)
Formula Reactant Remdesivir cyclic anhydride Product Remdesivir Alanine Metabolite (Ala-Met; GS-704277)
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013210 Remdesivir carboxylate Remdesivir cyclic anhydride Other reaction - Cyclization Remdesivir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013215 Remdesivir Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Unclear Remdesivir [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014047 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Unclear Remdesivir [2]
MR013212 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Oxidation - Deamination Remdesivir [1]
References
1 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
2 Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir

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