Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013215)
Formula Reactant Remdesivir Product Remdesivir Alanine Metabolite (Ala-Met; GS-704277)
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Cathepsin A (CTSA) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013220 Remdesivir GS-441524 Unclear Remdesivir [1]
MR013209 Remdesivir Remdesivir carboxylate Hydrolysis - Ester hydrolysis Remdesivir [2]
MR013218 Remdesivir Remdesivir M1 Unclear Remdesivir [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013211 Remdesivir cyclic anhydride Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Hydrolysis - Hydrolysis Remdesivir [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014047 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Unclear Remdesivir [3]
MR013212 Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Remdesivir Nucleoside Monophosphate Oxidation - Deamination Remdesivir [2]
References
1 Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19
2 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
3 Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir

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