Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013245)
Formula
CYP2C9 ...
SVG example
Oxidationn
Reactant Voriconazole Product Voriconazole N-Oxide Metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013250 Voriconazole 4-Hydroxyvoriconazole Oxidation - Hydrolyzationn Voriconazole [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013246 Voriconazole N-Oxide Metabolite UK-51,060 Unclear Voriconazole [1], [2]
References
1 The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human
2 Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6.

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