Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013286)
Formula Reactant Zafirlukast Product Zafirlukast metabolite M6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013278 Zafirlukast Zafirlukast metabolite M1 Hydrolysis - Hydrolysis Zafirlukast [1], [2]
MR013282 Zafirlukast Zafirlukast metabolite M5 Unclear Zafirlukast [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013287 Zafirlukast metabolite M6 Zafirlukast metabolite M7 Unclear Zafirlukast [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolism and excretion of zafirlukast in dogs, rats, and mice

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