Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013282)
Formula
CYP2C9 ...
SVG example
Reactant Zafirlukast Product Zafirlukast metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013278 Zafirlukast Zafirlukast metabolite M1 Hydrolysis - Hydrolysis Zafirlukast [1], [2]
MR013286 Zafirlukast Zafirlukast metabolite M6 Unclear Zafirlukast [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013283 Zafirlukast metabolite M5 Zafirlukast metabolite M8 Unclear Zafirlukast [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolism and excretion of zafirlukast in dogs, rats, and mice

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