Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013298)
Formula
CYP2C9 ...
SVG example
Hydrolyzationn
Reactant Dehydroxyzyleuton Product OH-dehydroxyzileuton
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013296 Zileuton Dehydroxyzyleuton Reduction - N-dehydroxylation Zileuton [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013297 Dehydroxyzyleuton Dehydroxyzileuton sulfoxide metabolite Oxidation - Sulfoxidation Zileuton [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.

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