Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013351)
Formula Reactant O-demethylated tetrandrine Product Quinone methide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013350 CBT-1 O-demethylated tetrandrine Oxidation - Demethylation CBT-1 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006292 Eugenol Quinone methide Unclear Eugenol [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013352 Quinone methide O-demethylated tetrandrine GSH conjugate Unclear CBT-1 [1]
References
1 CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine. Arch Toxicol. 2016 Jul;90(7):1737-48.
2 Applying sputum as a diagnostic tool in pneumonia: limited yield, minimal impact on treatment decisions

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