Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013627)
Formula
SVG example
Reactant SN-38 Product SN-38 G
Reactant Info Product Info
Metabolic Enzyme Beta-glucuronidase (GUSB) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007484 SN-38 SN-38G Conjugation - Glucuronidation SN-38 [1], [2]
MR013227 SN-38 10-O-glucuronyl-SN-38 Conjugation - O-gluccuronidation Sacituzumab govitecan [3]
MR001227 SN-38 Glucuronidated Sn-38 Conjugation - Glucuronidation Irinotecan hydrochloride [4], [5], [6]
References
1 Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
2 Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics
3 New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9
4 Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients Drug Metab Dispos. 2000 Apr;28(4):423-33.
5 Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: A new concept. Biochem Biophys Res Commun. 2023 Jul 12;665:19-25. doi: 10.1016/j.bbrc.2023.04.109.
6 Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model. Br J Pharmacol. 2023 May;180(10):1362-1378. doi: 10.1111/bph.16020.

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