Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013763)
Formula
CYP3A4 ...
SVG example
Reactant PPI-2458 Product PPI-2458 metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013759 PPI-2458 PPI-2458 metabolite M1 Oxidation - Hydroxylation PPI-2458 [1]
MR013760 PPI-2458 PPI-2458 metabolite M2 Unclear PPI-2458 [1]
MR013761 PPI-2458 PPI-2458 metabolite M3 Unclear PPI-2458 [1]
MR013762 PPI-2458 PPI-2458 metabolite M4 Oxidation - Hydroxylation PPI-2458 [1]
MR013764 PPI-2458 PPI-2458 metabolite M6 Unclear PPI-2458 [1]
References
1 Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. Drug Metab Dispos. 2013 Apr;41(4):814-26.

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