Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013759)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant PPI-2458 Product PPI-2458 metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013760 PPI-2458 PPI-2458 metabolite M2 Unclear PPI-2458 [1]
MR013761 PPI-2458 PPI-2458 metabolite M3 Unclear PPI-2458 [1]
MR013762 PPI-2458 PPI-2458 metabolite M4 Oxidation - Hydroxylation PPI-2458 [1]
MR013763 PPI-2458 PPI-2458 metabolite M5 Unclear PPI-2458 [1]
MR013764 PPI-2458 PPI-2458 metabolite M6 Unclear PPI-2458 [1]
References
1 Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. Drug Metab Dispos. 2013 Apr;41(4):814-26.

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