Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013768)
Formula
SVG example
Unclear
Reactant Phenylbutenoyl-CoA Product Beta-Hydroxyphenylbutyryl-CoA
Reactant Info Product Info
Metabolic Enzyme Enoyl-CoA hydratase (ECHS1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013767 Phenybutyryl-CoA Phenylbutenoyl-CoA Unclear - Unclear phenylbutyrate [1]
MR005597 Phenylbutyryl-CoA Phenylbutenoyl-CoA Unclear Sodium phenylbutyrate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005599 Beta-Hydroxyphenylbutyryl-CoA Beta-Ketophenylbutyryl-CoA Unclear Sodium phenylbutyrate [2]
MR013769 Beta-Hydroxyphenylbutyryl-CoA Beta-Ketophenylbutyryl-CoA Unclear - Unclear phenylbutyrate [1]
References
1 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
2 Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate

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