Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013776)
Formula Reactant 3,10-demethylpalmatine Product 2,3,10-trihydroxyberberine
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013775 Jatrorrhizine 3,10-demethylpalmatine Oxidation - Demethylation Berberine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013778 3,10-demethylpalmatine 3,10-demethylpalmatine-10-O-sulfate Unclear - Unclear Berberine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013780 Demethyleneberberine 2,3,10-trihydroxyberberine Oxidation - Demethylation Berberine [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013777 2,3,10-trihydroxyberberine 2,3,10-trihydroxyberberine-2-O-sulfate Conjugation - Sulfation Berberine [1]
References
1 The metabolism of berberine and its contribution to the pharmacological effects
2 CYP2D plays a major role in berberine metabolism in liver of mice and humans

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