| General Information of This Metabolic Reaction (MR) (ID:
MR013895) |
| Formula |
|
| Reactant |
Sildenafil |
Product |
N-desmethyl Sildenafil |
|
Reactant Info
|
Product Info
|
|
Metabolic Enzyme
|
Cytochrome P450 2D6 (CYP2D6)
|
DME Info
|
|
Cytochrome P450 2C9 (CYP2C9)
|
DME Info
|
|
Cytochrome P450 3A5 (CYP3A5)
|
DME Info
|
|
Cytochrome P450 3A4 (CYP3A4)
|
DME Info
|
|
Cytochrome P450 3A7 (CYP3A7)
|
DME Info
|
|
Metabolic Type
|
Unclear
-
Unclear
|
|
|
|
|
|
|
|
| Other MR(s) Related to The Product of This MR |
|
Other MR(s) That Produce The Product of This MR
|
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|
| References |
| 1 |
The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90.
|
| 2 |
Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. Br J Clin Pharmacol. 2002;53 Suppl 1(Suppl 1):5S-12S. doi: 10.1046/j.0306-5251.2001.00027.x.
|
| 3 |
Erectile dysfunction drugs changed the protein expressions and activities of drug-metabolising enzymes in the liver of male rats. Oxid Med Cell Longev. 2016;2016:4970906.
|
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