Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR014166)
Formula	CYP3A4 ... Oxidation
	Reactant	Ciclosporin	Product	AM4N
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)				DME Info
Metabolic Enzyme					DME Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR014160	Ciclosporin	AM1	Oxidation - Oxidation	Ciclosporin	[1]
MR014164	Ciclosporin	AM9	Oxidation - Hydroxylation	Ciclosporin	[2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR014189	AM4N	AM4N9	Unclear - Unclear	Ciclosporin	[1]

References
1	Cyclosporin metabolism in transplant patients
2	High-performance liquid chromatographic method for the simultaneous determination of cyclosporine A and its four major metabolites in whole blood Talanta. 2005 Feb 15;65(3):638-43. doi: 10.1016/j.talanta.2004.07.048.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.