Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00148)
Xenobiotics Name
Bosentan
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
104865
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [1]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [1]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [1]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [1]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2], [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2], [1]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
References
1 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
2 Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. Drug Metab Dispos. 2008 Jun;36(6):1046-55.

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