Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00310)
Xenobiotics Name
Nelfinavir mesylate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
64142
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 0.55 microM [1]
Cytochrome P450 3A5 (CYP3A5) DME Info Ki = 0.57 microM [2]
References
1 Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25.
2 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.
3 Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors. Sci Rep. 2018 Jan 18;8(1):1115.

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