Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00319)
Xenobiotics Name
Pioglitazone hydrochloride
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
60560
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Carboxylesterase 1 (CES1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [1]
References
1 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
2 Human and rodent carboxylesterases: immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, and tumor-related expression. Drug Metab Dispos. 2002 May;30(5):541-7.

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