Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00405)
Xenobiotics Name
Niclosamide
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
4477
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1], [2]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1], [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [3]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [3]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [4]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [5]
NADH-ubiquinone oxidoreductase 20 kDa (NDUFS7) DME Info Homo sapiens [6]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [3]
DME(s) Induced by This Xenobiotics
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [7], [8]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
References
1 Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014 Aug;134(2):362-72.
2 Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol. 2015 Mar;135(3):712-20.
3 New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing. Antimicrob Agents Chemother. 2013 Feb;57(2):996-1005.
4 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
5 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
6 Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem. 2012 Jul 20;287(30):25292-302.
7 Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. J Biol Chem. 2006 Dec 22;281(51):39022-32.
8 JNK1, but not JNK2, is required for COX-2 induction by nickel compounds. Carcinogenesis. 2007 Apr;28(4):883-91.

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