Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00505)
Xenobiotics Name
Melatonin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
896
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Alkaline phosphatase (ALPL) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A1 (CYP1A1) DME Info Ki = 59 microM [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Ki = 12 microM [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Ki = 14 microM [2]
References
1 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
2 Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.
3 The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Mol Endocrinol. 2005 May;19(5):1170-80.

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