Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00597)
Xenobiotics Name
Camptothecin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
24360
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [1]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Friedreich ataxia protein (FXN) DME Info Homo sapiens [3]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [4]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [5]
Thymidylate synthase (TYMS) DME Info Homo sapiens [2]
References
1 Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018 Apr;92(4):1435-1451.
2 Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 2006 Feb;41(2):140-50.
3 Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia. PLoS One. 2013;8(2):e55940.
4 GSTP1 affects chemoresistance against camptothecin in human lung adenocarcinoma cells. Cancer Lett. 2004 Dec 8;216(1):89-102.
5 Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes. Environ Toxicol. 2019 Apr;34(4):401-414.

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