Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00776)
Xenobiotics Name
Polychlorinated biphenyls
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Carcinogen
Structure
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3D MOL 2D MOL
PubChem CID
6636
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2], [3]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [4]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5]
References
1 Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway. J Toxicol Sci. 2014 Apr;39(2):353-61.
2 The activities of several detoxication enzymes are differentially induced by juices of garden cress, water cress and mustard in human HepG2 cells. Chem Biol Interact. 2004 Dec 7;150(3):211-9.
3 Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes. Food Chem Toxicol. 2013 Jun;56:231-9.
4 Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling. PLoS One. 2014 Jul 22;9(7):e101959.
5 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013 Jun;72:69-82.

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