Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00917)
Xenobiotics Name
Polychlorinated dibenzodioxin
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Environmental Pollutant
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=15625"></iframe>
3D MOL 2D MOL
PubChem CID
15625
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3], [4]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [5]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [7]
References
1 Gnetin H isolated from Paeonia anomala inhibits FcRI-mediated mast cell signaling and degranulation. J Ethnopharmacol. 2014 Jul 3;154(3):798-806.
2 Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells. Toxicol Lett. 2019 Oct 1;313:66-76.
3 Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling. PLoS One. 2014 Jul 22;9(7):e101959.
4 Red wine extract protects against oxidative-stress-induced endothelial senescence. Clin Sci (Lond). 2012 Oct;123(8):499-507.
5 Human cytochrome p450 2s1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine. Drug Metab Dispos. 2005 Mar;33(3):336-40.
6 Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2005;19(3):149-53.
7 Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne. Toxicol Lett. 2008 Apr 1;177(3):182-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.