Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00921)
Xenobiotics Name
Perfluorooctane sulfonic acid
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Health Hazard/Toxicant
Structure
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3D MOL 2D MOL
PubChem CID
74483
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [2]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [3]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [4]
Peroxisomal multifunctional enzyme 2 (HSD17B4) DME Info Homo sapiens [5]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [6]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [7]
Adenine phosphoribosyltransferase (APRT) DME Info Homo sapiens [8]
Catalase (CAT) DME Info Homo sapiens [8]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [8]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [9]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [8]
Glutamine amidotransferase (GMPS) DME Info Homo sapiens [10]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [11]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [12]
References
1 Role of miR-155 in fluorooctane sulfonate-induced oxidative hepatic damage via the Nrf2-dependent pathway. Toxicol Appl Pharmacol. 2016 Mar 15;295:85-93.
2 The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29.
3 Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells. Toxicol Lett. 2009 Feb 25;185(1):23-31.
4 Metabolic activation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human prostate. Toxicol Sci. 2018 Jun 1;163(2):543-556.
5 Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology. 2011 Apr 11;282(3):146-53.
6 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
7 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
8 Effects of brominated flame retardants and brominated dioxins on steroidogenesis in H295R human adrenocortical carcinoma cell line. Environ Toxicol Chem. 2007 Apr;26(4):764-72.
9 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
10 Hierarchical cluster analysis of environmental pollutants through P450 induction in cultured hepatic cells. Ecotoxicol Environ Saf. 1996 Aug;34(3):205-15.
11 Modulation of signal transduction pathways in lymphocytes due to sub-lethal toxicity of chlorinated phenol. Toxicol Lett. 2008 Jun 10;179(1):23-8.
12 A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol. 2004 Dec 15;68(12):2347-58.

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