Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01089)
Xenobiotics Name
1,4-naphthoquinone
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
8530
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [3]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [5]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [5]
References
1 Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells. Hum Reprod. 2010 Sep;25(9):2229-38.
2 Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator. J Toxicol Sci. 2016;41(6):775-781.
3 In vitro toxicity of naphthalene, 1-naphthol, 2-naphthol and 1,4-naphthoquinone on human CFU-GM from female and male cord blood donors. Toxicol In Vitro. 2008 Sep;22(6):1555-61.
4 Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim Biophys Acta. 2005 Sep 10;1745(2):156-65.
5 Induction of cyclooxygenase-2 mRNA and protein expression by epoxy resin and zinc oxide-eugenol based root canal sealers in human osteoblastic cells. Biomaterials. 2003 May;24(11):1869-75.

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